Neuronox® Botulinum Toxin

• Botulinum Toxin is a protein secreted and purified from Clostridium botulinum (Clostridium Botulinum) during its reproduction, first discovered by Dr. Ermergem in 1897. According to antigenic differences, botulinum toxin is classified into seven serotypes, A through G, of which Type A is the most widely used in medical and aesthetic medicine fields due to its high safety and stability.
• Botulinum toxin is a neurotransmission modulator that temporarily inhibits the release of acetylcholine from nerve endings, reducing excessive muscle contraction and relaxing specific muscles. This property was originally applied to medical treatments such as strabismus and muscle spasms. As clinical research has advanced, its effectiveness in improving dynamic wrinkles, preventing fine line formation, and refining facial contours has gradually been confirmed, making it one of the most popular minimally invasive aesthetic treatments worldwide today.

Before receiving botulinum toxin, please be sure to note the following to ensure safety and treatment effectiveness:

1️⃣ Contraindicated Groups

• Those allergic to botulinum toxin or any component of the agent
• Patients with neuromuscular diseases such as myasthenia gravis or motor neuron degeneration
• Those with severe psychiatric disorders or mental impairments
• Patients with cardiovascular or major organ diseases
• Those who are pregnant or breastfeeding

2️⃣ Skin Condition

If the injection site is currently infected, allergic, or inflamed, wait until symptoms subside before injection

3️⃣ Medications & Supplements

Those taking anticoagulants, aspirin, ginseng, fish oil, ginkgo, vitamin E, or other medications or foods that may increase bruising can still receive the injection, but have a higher chance of bruising

If taking any other medications, please inform the physician truthfully

4️⃣ Special Populations

Those under 18 or without legal capacity must be accompanied by a guardian for the visit and to sign the consent form

Those with respiratory diseases or a history of surgery should proactively inform the physician

5️⃣ Physician Evaluation

A complete evaluation by a qualified physician is required before injection to determine treatment feasibility and dosage safety

Reminder: If you have any discomfort or concerns, please be sure to communicate with your physician to ensure the treatment is safe and the results natural.

1 Post-Procedure Care & Lifestyle Advice

For 4 hours after injection, do not lie flat, lower your head, or massage the injection site, to prevent the agent from spreading.

For 24 hours after injection, avoid massaging or tugging the injected area.

For one week after the procedure, massage or any treatment of the injection site is prohibited.

2 Avoid Strenuous Activity & High Heat

For 72 hours after injection, avoid strenuous exercise.

For one week, high-temperature environments such as saunas, hot springs, ovens, steam rooms, or sauna rooms are prohibited.

For two weeks, avoid prolonged sun exposure, SPA, and washing the face with hot water.

3 Watch for Medications & Bruising

Those taking aspirin or anticoagulants have a higher chance of bruising or bleeding.

If bruising or redness/swelling occurs at the injection site, moderate ice application can soothe it.

4 Special Site Considerations

Calf muscle injection: minimize wearing high heels, prolonged standing, and intense leg exercise.

Facial wrinkle removal: results gradually appear after about 1 week.

Face slimming / calves: results gradually appear in about 3 weeks to 1 month.

5 Medications & Care

For 1 week after injection, avoid using retinoic acid (A-acid) or fruit acid products

Treatment results take time, please be patient

If any abnormal condition occurs, please contact the clinic immediately

💡 Reminder: Following the post-procedure precautions can prevent the agent from spreading, reduce the risk of side effects, and make the treatment results more stable and natural.

Q1 Where can botulinum toxin be injected?

Mainly used to relax muscles. Common areas include:

• Facial dynamic wrinkles: crow's feet, forehead lines
• Facial sculpting: masseter slimming, jawline lifting
• Body lines: calf muscle slimming
• Hyperhidrosis treatment

Q2 Will muscle weakness occur after injection?

If the dosage is too high or the placement imprecise, you may temporarily feel muscle weakness, but it usually recovers as the effect wears off, leaving no aftereffects. Choosing a qualified professional physician reduces the risk.

Q3 Is botulinum toxin price related to effectiveness?

You get what you pay for. Botulinum treatments priced too low may use insufficient dosage or have unclear product sources. We recommend choosing a safe, reliable brand and physician, and not risking safety for a small price difference.

Q4 How much dosage do I need?

It varies by area and improvement needs:

• Expression lines: 8–16U per area
• Face slimming / jawline: 30–60U
• Calf muscle: 160–200U
• Hyperhidrosis: 50–100U per area

The above is for reference only; the actual dosage must be determined by a physician's evaluation.

Q5 How long does the botulinum effect last?

Generally 4–6 months, related to metabolic rate, frequency of muscle use, lifestyle, stress, etc.

• Dynamic wrinkles: effect felt in 1–2 weeks, full effect about 1–2 months
• Facial lifting / masseter: muscle softening felt in about 3–4 weeks, full effect 1–2 months
• Calf muscle: muscle softening in about 1–2 months, full effect 1–3 months
• Hyperhidrosis: reduced sweating felt in about 3 weeks, full effect 1–2 months

Q6 Will botulinum injection make expressions stiff?

With professional physician evaluation and precise injection, natural expressions can usually be maintained. The first injection may require adjusting to the change in muscle strength, but will not be overly stiff.

Q7 How often do I need an injection?

One injection every 4–6 months is recommended; if you wish to maintain optimal condition, you can repeat the injection before the effect wears off, but this depends on individual constitution and needs.

Q8 Will wrinkles get worse after stopping injections?

No. After the effect wears off, the muscles resume their original activity, and wrinkles return to their pre-injection state, but will not be worse than before. Continued injection can delay wrinkle formation and the deepening of muscle lines.

Q9 How can I make the effect last longer?

Following physician advice, repeating injection before the effect wears off can accumulate effects, making wrinkle improvement longer-lasting.

Q10 What treatments can botulinum toxin be combined with?

Facial: picosecond laser, ultrasound lifting, thread lifting, hyaluronic acid, or Ellanse filling.